
Many believe the first clandestine labs originated in the California bay area from this environment around 1962. This supply began to wither in the 1960s as law enforcement prosecuted over-prescribing doctors and placed pressure on pharmaceutical companies to withdraw certain products. By the 1950s stimulants became a regular part of the American routine, and a flourishing black-market in diverted pharmaceuticals soon developed. Meth's psychostimulant effect does not seem to have been noticed until the mid-30s when Friedrich Hauschild discovered it at the Berlin based pharmaceutical company Temmler.

N-methyl-1-phenylpropan-2-amine or methamphetamine was first synthesized from the naturally occurring alkaloid ephedrine by Japanese chemist Nagai Nagayoshi in 1893 while researching the structure of ephedrine.
